Uhlu Lokuhlola I-Ethylene Oxide Sterilization Audit (ISO 11135)

Lolu hlu lokuhlola lokuhlola luklanyelwe abakhiqizi bemishini yezokwelapha kanye nabacwaningi mabhuku bekhwalithi ukuthi baluhlole I-Ethylene Oxide (EO) izinqubo zokuvala inzalo. Iqinisekisa ukuhambisana ngokugcwele nayo I-ISO 11135-1 futhi ISO 13485 izindinganiso.

1. Ububanzi

Lolu hlu lokuhlola lusebenza ezinqubweni zokuvala inzalo emikhiqizweni yezokwelapha eyenziwa nge-ethylene oxide. Okwemikhiqizo eyinyumba ye I-Risk Class III, imibhalo yokuklama nokuqinisekiswa kufanele ihlolwe. Ukuhlolwa kokuvala inzalo kufanele kwenziwe ngokusekelwe efayeleni lomkhiqizo okungenani elilodwa.

2. Izibopho kanye Negunya

Umcwaningi mabhuku oholayo

Ubhekene nokuhlolwa kohlelo lwe-QM mayelana ne-ISO 13485 kanye neSiqondiso soMkhandlu 93/42/EWG. Umcwaningi mabhuku oholayo wengamela ithimba labacwaningi mabhuku futhi aqinisekise ukuthotshelwa kwenqubo ye-DQS.

Uchwepheshe Wezobuchwepheshe

Ibophezelekile ekuhloleni okuqondene nomkhiqizo othile, okugxile kakhulu ekubhalweni komklamo kanye nokuqinisekiswa kwezinqubo zokuvala inzalo.

3. Indlela Yokuhlola

Umgomo ukuhlola ukugcwaliseka I-ISO 11135-1. Imiphumela kufanele yenziwe embikweni wocwaningomabhuku ngokubhekiselwa kulolu hlu lokuhlola.

Ukhiye Wokuhlola: 1 = Kufeziwe | 2 = Ngokwengxenye (Yamukelekile) | 3 = Ngokwengxenye (Akumukeleki) | 4 = Akufezwanga | NA = Ayisebenzi
Umshwana Audit Umbuzo / Imfuneko Ukuhlola
4. Izinhlelo Zokuphatha Ikhwalithi
4.1 Imibhalo
4.1.1Ingabe izinqubo zokuklama, ukuqinisekiswa, ukulawula okujwayelekile kanye nokukhishwa komkhiqizo ekubulaweni inzalo kucacisiwe?
4.1.2Ingabe yonke imibhalo namarekhodi ngokwe-ISO 11135-1 abuyekeziwe, avunyelwe futhi ayalawulwa?
4.2 Isibopho Sokuphatha
4.2.1Ingabe izibopho neziphathimandla zicacisiwe futhi zabelwa abantu abaqeqeshiwe?
4.2.2Ingabe sikhona isivumelwano senkontileka uma kunezinhlangano ezimbalwa ezihilelekile?
4.3 Ukwenziwa Komkhiqizo
4.3.1-2Ingabe izinqubo zokuthenga, ukuhlonza nokulandeleka zicacisiwe?
4.3.3Ingabe uhlelo lokulinganiswa kwazo zonke izisetshenziswa namathuluzi okuhlola lucacisiwe?
4.4 Izilinganiso, Ukuhlaziya kanye Nokuthuthukisa
4.4Ingabe izinqubo zokulawula umkhiqizo ongavumelani nezenzo zokulungisa/zokuvikela zicacisiwe?
5. Ukwenziwa kwe-ejenti yokuvala inzalo
5.1Ingabe ukwakheka, izimo zokugcina nobude bendawo bucaciswe i-ejenti ye-EO?
5.2Ingabe ukusebenza kahle kwe-microbicidal kuyasetshenziswa uma kusetshenziswa izingoma ezingajwayelekile?
5.3Ukuhlolwa kwemiphumela kumkhiqizo ngokweSigaba 7.
5.4.1Ukuhlolwa komphumela wemvelo okubhaliwe kanye nezenzo zokuqapha?
5.4.2Ukugcinwa kwemithetho yendawo/yezwe lonke mayelana nokukhishwa kwe-EO nokulahlwa kwayo?
6. Inqubo kanye Nezinsimbi Izinhlamvu
6.1.2Ingabe ukufakwa kwezinhlamvu kufaka phakathi ukulungiswa kwangaphambili, umjikelezo, kanye nokukhipha umoya?
6.1.3Ingabe umjikelezo uhlanganisa ukukhishwa komoya, ukufakwa kwe-EO, ukulungiswa, nokuhlanzwa?
6.1.4Ingabe (ngaphambi) ukwelashwa kwenziwa ngaphansi kokuswakama okulawulwayo nezinga lokushisa?
6.1.5-6Ingabe izinqubo eziguquguqukayo (izinga lokushisa, umswakama, i-EO conc, isikhathi) zicaciswe ngokubekezelela?
6.2.1-2Ukucaciswa kwezinto zokusebenza okubhalwe phansi okuhlanganisa nencazelo yawo wonke amathuluzi okuqapha?
6.2.3Ubufakazi be-software bokuxhumana nemininingwane (ISO 9000-3)?
6.2.4Ingabe ukwehluleka kokulawula AKUTHI kuthinti umsebenzi wokurekhoda?
7. Incazelo Yomkhiqizo
7.1.1-2Izinyathelo ezithathiwe zemikhiqizo emisha/eshintshiwe noma ukulayisha ukucupha? Ukulingana kubhaliwe?
7.1.3-5Ukufakwa/ukususwa kwe-EO ezingxenyeni okunzima kakhulu ukuvala inzalo kufakazelwe?
7.2.1-5Ukuphepha komkhiqizo: umthelela wokuvala inzalo okuningi, ukuphepha kwebhayoloji (ISO 10993), nezinsalela ze-EO?
7.3.1-2Ukulinganisa kwe-Bioburden (ISO 11737-1) nokuhlola ukusebenza kahle kokuhlanza (ISO 17664)?
8. Incazelo Yenqubo
8.1-4Inqubo yokuvala inzalo ecaciswe futhi isekelwa imibhalo ye-IQ/PQ?
8.5-7Ukusebenza kwe-Microbial kunqunyiwe (Isijobelelo A/B)? Izinkomba ze-BI ziyahambisana ne-ISO 11138?
8.8-9Ukuthobela izinkomba zamakhemikhali (ISO 11140) kanye nezivivinyo zokuthi sterility (ISO 11737-2)?
9. Ukuqinisekisa (IQ, OQ, PQ)
9.1 Ukufaneleka Kokufaka (IQ)
9.1.1-6Ukuthotshelwa kwezisetshenziswa, izikimu zobuchwepheshe, kanye nemininingwane yendawo yokufaka isunguliwe?
9.2 Ukufaneleka Kokusebenza (OQ)
9.2.1-2Ubufakazi bekhono lemishini yokusebenza ngaphakathi kokubekezelelana; ukulinganisa kuqinisekisiwe?
9.3 Iziqu Zokusebenza (PQ)
9.3.1-3Ubufakazi bokusebenza obufanayo, i-PQ ye-microbiological, kanye ne-PQ yomzimba (imigijimo emi-3 elandelanayo)?
9.4Izinguquko ekucushweni kokulayisha zihlolwe umthelela we-SAL?
9.5.1-6Ukubuyekezwa kombiko wokuqinisekisa nokuvunywa; Imibandela yokukhishwa kwepharamethikhi icacisiwe?
10. Ukuqapha Nokulawula Umjikelezo
10.1Ukuqapha izinga lokushisa, ingcindezi, umswakama, ukugxila kwe-EO, nokujikeleza kwegesi?
10.2Ukukhishwa kwe-Parametric: ukulinganisa izinga lokushisa kwamaphoyinti angu-2 nokuhlaziywa kwe-EO okuqondile?
11. Ukukhishwa koMkhiqizo eNzalweni
11.1Imibandela ebhaliwe yokuvumelana (amarekhodi edatha uma iqhathaniswa nokucaciswa)?
11.2Ukuphatha imikhiqizo engavumelani (ISO 13485) uma okuguquguqukayo noma i-BI yehluleka?
12. Ukugcina Inqubo Esebenzayo
12.1-2Ubufakazi bokusebenza kahle ngezikhathi ezithile kanye nokuhlelwa kokulungisa okuvimbelayo?
12.3.1-8Inqubo yokuhlola kabusha (iminyaka yonke yokukhululwa kwe-parametric); Ukuhlolwa kokufaneleka kwe-BI?
12.4.1-3Ukuhlolwa kwezinguquko (impahla/umkhiqizo/umenzeli) nencazelo yezinga lokuqinisekisa?

Umshwana wokuzihlangula: Lolu hlu lokuhlola luyinkomba. Ngaso sonke isikhathi bheka izinga elisemthethweni le-ISO 11135:2014 mayelana nokuhanjiswa okulawulwayo.

Skrolela phezulu